Article: Subgroups of parvalbumin-expressing interneurons in layers 2/3 of the visual cortex.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Helm J; Akgul G; Wollmuth LP J. Neurophysiol., 2013
PV1a | PV1b | PV2 | PV3 | Tukey Test | |
---|---|---|---|---|---|
Passive | |||||
Vm, mV | -72 ± 2 | -77 ± 1 | -77 ± 2 | -83 ± 1 | 1a, 3 2, 3 |
Cm, pF | 20.4 ± 1.2 | 20.4 ± 1.1 | 19.4 ± 0.6 | 18.4 ± 0.8 | N.D. |
Rm, MΩ | 84 ± 8 | 129 ± 13 | 104 ± 5 | 213 ± 20 | 1a, 3 1b, 3 2, 3 |
Rheobase, pA | 570 ± 60 | 320 ± 30 | 400 ± 20 | 200 ± 20 | 1a, 1b 1a, 2 1a, 3 1b, 3 2, 3 |
AP shape | |||||
AP threshold, mV | -25.8 ± 2.4 | -30.4 ± 1.9 | -39.5 ± 1.3 | -42.3 ± 1.4 | 1a, 2 1a, 3 1b, 2 1b, 3 |
AP peak, mV | 21.1 ± 2.8 | 23.2 ± 2.1 | 16.0 ± 2.0 | 12.2 ± 2.8 | 1b, 3 |
AP 1/2-width, ms | 0.40 ± 0.03 | 0.48 ± 0.03 | 0.48 ± 0.02 | 0.73 ± 0.03 | 1a, 3 1b, 3 2, 3 |
AHP peak, mV | -26.9 ± 1.2 | -27.0 ± 0.6 | -23.4 ± 0.5 | -23.9 ± 0.7 | 1a, 2 1b, 2 1b, 3 |
AHP latency, ms | 1.4 ± 0.1 | 2.1 ± 0.2 | 1.7 ± 0.1 | 3.7 ± 0.4 | 1a, 3 1b, 3 2, 3 |
AHP area, V·s | 170 ± 20 | 270 ± 10 | 180 ± 10 | 390 ± 40 | 1a, 1b 1a, 3 1b, 2 1b, 3 2, 3 |
Firing pattern | |||||
Delay 1st AP, ms | 360 ± 130 | 590 ± 60 | 490 ± 60 | 460 ± 60 | N.D. |
Δ amplitude, mV | 5.3 ± 1.7 | -2.2 ± 0.8 | 2.2 ± 0.8 | 0.7 ± 0.8 | 1a, 1b 1a, 3 1b, 2 |
ISI average, ms | 12.9 ± 1.0 | 26.8 ± 0.8 | 29.5 ± 0.7 | 30.5 ± 0.9 | 1a, 1b 1a, 2 1a, 3 1b, 3 |
Frequency adapt. | 0.98 ± 0.12 | 0.96 ± 0.06 | 1.22 ± 0.38 | 0.89 ± 0.11 | N.D. |
Max. inst. freq., Hz | 95.9 ± 6.0 | 45.6 ± 1.6 | 66.7 ± 4.4 | 43.2 ± 2.0 | 1a, 1b 1a, 2 1a, 3 1b, 2 2, 3 |
Min. inst. freq., Hz | 59.5 ± 7.1 | 29.0 ± 1.9 | 8.6 ± 1.1 | 20.4 ± 2.6 | 1a, 1b 1a, 2 1a, 3 1b, 2 2, 3 |
Max/min inst. | 1.8 ± 0.3 | 2.0 ± 0.5 | 13.8 ± 2.6 | 4.5 ± 1.5 | 1a, 2 1b, 2 2, 3 |
CV frequency | 0.08 ± 0.01 | 0.09 ± 0.01 | 0.27 ± 0.01 | 0.13 ± 0.01 | 1a, 2 1b, 2 2, 3 |
I/F slope | 0.6 ± 0.2 | 1.5 ± 0.2 | 2.4 ± 0.3 | 2.1 ± 0.2 | 1a, 2 1a, 3 1b, 2 |
Age, dpn | 18.1 ± 0.2 | 17.3 ± 0.3 | 16.2 ± 0.2 | 16.4 ± 0.3 | 1a, 2 1a, 3 1b, 2 |
No. of interneurons | 11 | 22 | 31 | 18 | |
B13 | 0 | 3 | 5 | 1 | |
PV-tdTomato | 11 | 19 | 26 | 17 |
Values are means ± SE. PV subgroups identified by k-means cluster analysis (k = 4) are characterized by passive membrane properties, action potential (AP) shape, and firing pattern (see materials and methods). Listed are the 17 properties used for clustering plus 2 additional parameters: maximum instantaneous frequency and the maximum-to-minimum instantaneous frequency ratio (Max/Min inst.). Vm, membrane potential; Cm, membrane capacitance; Rm, membrane resistance; AHP, afterhyperpolarization; ISI, interspike interval; CV, coefficient of variation; dpn, postnatal day. ANOVA followed by Tukey test (P < 0.05) was used to identify significant differences between subgroup parameters. N.D., none of the subgroups was significantly different.
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
---|---|---|---|---|---|
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing continuous-firing high-frequency interneuron | resting membrane potential (mV) | -72.0 ± 2.0 (11) | -72.0 (mV) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing continuous-firing interneuron | resting membrane potential (mV) | -77.0 ± 1.0 (22) | -77.0 (mV) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing strongly stuttering interneuron | resting membrane potential (mV) | -77.0 ± 2.0 (31) | -77.0 (mV) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing weakly stuttering interneuron | resting membrane potential (mV) | -83.0 ± 1.0 (18) | -83.0 (mV) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing continuous-firing high-frequency interneuron | cell capacitance (pF) | 20.4 ± 1.2 (11) | 20.4 (pF) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing continuous-firing interneuron | cell capacitance (pF) | 20.4 ± 1.1 (22) | 20.4 (pF) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing strongly stuttering interneuron | cell capacitance (pF) | 19.4 ± 0.6 (31) | 19.4 (pF) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing weakly stuttering interneuron | cell capacitance (pF) | 18.4 ± 0.8 (18) | 18.4 (pF) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing continuous-firing high-frequency interneuron | input resistance (MΩ) | 84.0 ± 8.0 (11) | 84.0 (MΩ) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing continuous-firing interneuron | input resistance (MΩ) | 129.0 ± 13.0 (22) | 129.0 (MΩ) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing strongly stuttering interneuron | input resistance (MΩ) | 104.0 ± 5.0 (31) | 104.0 (MΩ) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing weakly stuttering interneuron | input resistance (MΩ) | 213.0 ± 20.0 (18) | 213.0 (MΩ) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing continuous-firing high-frequency interneuron | rheobase (pA) | 570.0 ± 60.0 (11) | 570.0 (pA) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing continuous-firing interneuron | rheobase (pA) | 320.0 ± 30.0 (22) | 320.0 (pA) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing strongly stuttering interneuron | rheobase (pA) | 400.0 ± 20.0 (31) | 400.0 (pA) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing weakly stuttering interneuron | rheobase (pA) | 200.0 ± 20.0 (18) | 200.0 (pA) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing continuous-firing high-frequency interneuron | spike threshold (mV) | -25.8 ± 2.4 (11) | -25.8 (mV) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing continuous-firing interneuron | spike threshold (mV) | -30.4 ± 1.9 (22) | -30.4 (mV) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing strongly stuttering interneuron | spike threshold (mV) | -39.5 ± 1.3 (31) | -39.5 (mV) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing weakly stuttering interneuron | spike threshold (mV) | -42.3 ± 1.4 (18) | -42.3 (mV) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing continuous-firing high-frequency interneuron | spike peak (mV) | 21.1 ± 2.8 (11) | 21.1 (mV) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing continuous-firing interneuron | spike peak (mV) | 23.2 ± 2.1 (22) | 23.2 (mV) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing strongly stuttering interneuron | spike peak (mV) | 16.0 ± 2.0 (31) | 16.0 (mV) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing weakly stuttering interneuron | spike peak (mV) | 12.2 ± 2.8 (18) | 12.2 (mV) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing continuous-firing high-frequency interneuron | spike width (ms) | 0.4 ± 0.03 (11) | 0.4 (ms) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing continuous-firing interneuron | spike width (ms) | 0.48 ± 0.03 (22) | 0.48 (ms) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing strongly stuttering interneuron | spike width (ms) | 0.48 ± 0.02 (31) | 0.48 (ms) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing weakly stuttering interneuron | spike width (ms) | 0.73 ± 0.03 (18) | 0.73 (ms) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing continuous-firing high-frequency interneuron | AHP voltage (mV) | -26.9 ± 1.2 (11) | -26.9 (mV) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing continuous-firing interneuron | AHP voltage (mV) | -27.0 ± 0.6 (22) | -27.0 (mV) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing strongly stuttering interneuron | AHP voltage (mV) | -23.4 ± 0.5 (31) | -23.4 (mV) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing weakly stuttering interneuron | AHP voltage (mV) | -23.9 ± 0.7 (18) | -23.9 (mV) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing continuous-firing high-frequency interneuron | AHP duration (ms) | 1.4 ± 0.1 (11) | 1.4 (ms) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing continuous-firing interneuron | AHP duration (ms) | 2.1 ± 0.2 (22) | 2.1 (ms) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing strongly stuttering interneuron | AHP duration (ms) | 1.7 ± 0.1 (31) | 1.7 (ms) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing weakly stuttering interneuron | AHP duration (ms) | 3.7 ± 0.4 (18) | 3.7 (ms) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing continuous-firing high-frequency interneuron | first spike latency (ms) | 360.0 ± 130.0 (11) | 360.0 (ms) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing continuous-firing interneuron | first spike latency (ms) | 590.0 ± 60.0 (22) | 590.0 (ms) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing strongly stuttering interneuron | first spike latency (ms) | 490.0 ± 60.0 (31) | 490.0 (ms) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing weakly stuttering interneuron | first spike latency (ms) | 460.0 ± 60.0 (18) | 460.0 (ms) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing continuous-firing high-frequency interneuron | adaptation ratio (last/first ISI) | 0.98 ± 0.12 (11) | 0.98 (ratio) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing continuous-firing interneuron | adaptation ratio (last/first ISI) | 0.96 ± 0.06 (22) | 0.96 (ratio) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing strongly stuttering interneuron | adaptation ratio (last/first ISI) | 1.22 ± 0.38 (31) | 1.22 (ratio) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing weakly stuttering interneuron | adaptation ratio (last/first ISI) | 0.89 ± 0.11 (18) | 0.89 (ratio) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing continuous-firing high-frequency interneuron | maximum firing rate (Hz) | 95.9 ± 6.0 (11) | 95.9 (Hz) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing continuous-firing interneuron | maximum firing rate (Hz) | 45.6 ± 1.6 (22) | 45.6 (Hz) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing strongly stuttering interneuron | maximum firing rate (Hz) | 66.7 ± 4.4 (31) | 66.7 (Hz) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing weakly stuttering interneuron | maximum firing rate (Hz) | 43.2 ± 2.0 (18) | 43.2 (Hz) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing continuous-firing high-frequency interneuron | FI slope | 0.6 ± 0.2 (11) | 0.6 (Hz/nA) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing continuous-firing interneuron | FI slope | 1.5 ± 0.2 (22) | 1.5 (Hz/nA) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing strongly stuttering interneuron | FI slope | 2.4 ± 0.3 (31) | 2.4 (Hz/nA) | Data Table |
Neocortex interneuron deep | Visual Cortex layer 2/3 parvalbumin-expressing weakly stuttering interneuron | FI slope | 2.1 ± 0.2 (18) | 2.1 (Hz/nA) | Data Table |